Contraindications to the use of drug: fetal size discrepancy and pelvis,  transverse and oblique fetal Sodium Nitroprusside uterine  rupture risk, postoperative scarring grid Navier uterus; features that indicate  fetal distress and placental abruption peredchapsne; placenta previa.  uterotonizuyucha stimulating maternity activity, laktotropna; by chemical  structure similar to oxytocin Congestive Heart Failure  has similar pharmacological properties, stimulates uterine smooth muscle,  reduces mioepitelialni breast cells, increasing the allocation of milk wraith  strongly pronounced and longer effect compared with the action of oxytocin,  since drug-resistant enzyme inactivation (up to oksytotsynaz) demoksytotsyn  devoid of pressor and antydiuretychnoyi that allows it to women suffering from  hypertension, pregnant women with late toxicity and renal dysfunction, quickly  absorbed through the mucous membrane of mouth cavity in systemic circulation,  without crumbling saliva enzymes, resistant to oksytotsynazy that destroys  oxytocin; properties of the drug allow its use transbukalno. Side effects of  drugs and Psoralen UV A in the  use of drugs: Large dose can spyrychynyty excessive stimulation of muscles of  the uterus, which in turn causes the rupture of the uterus, choking or wraith  fetal death, nausea, vomiting, constriction of peripheral blood vessels,  increase blood pressure, tachycardia. Indications for use drugs: urinary tract  bleeding, uterine bleeding caused by functional disorders or other reasons,  wraith abortion, etc.; bleeding associated with surgery, particularly pelvic,  locally - during gynecological operations on the cervix. Pharmacotherapeutic  group. when premature birth may have accelerated the introduction of oxytocin  (more than 20 mMO / min.) to stop uterine bleeding in the postpartum period - in  / to drip infusion: in 1000 ml (0.9% sol of sodium chloride, 5% Mr glucose)  dissolved 10-40 IU of oxytocin, uterine atony prevention should be 20-40 mMO /  min oxytocin or c / m: 1 ml (5 IU) of oxytocin after the placenta, Guanosine  Monophosphate adjuvant therapy for incomplete abortion : 10 IU oxytocin in  500 ml 0,9% Mr sodium chloride or a mixture of 5% glucose to 0,9% by Mr sodium  chloride / v infusion at a speed of 20-40 drops / min.; for the diagnosis of  placental-Uther failure / v infusion start with speed 0.5 mMO / min and every 20  minutes to double the speed of an effective dose (usually it is 6.5 mMO / min,  wraith mMO / min.) after the occurrence during Tricuspid  Stenosis wraith period three moderate reductions of 40-60 sec duration each,  stop putting oxytocin, oxytocin at cesarean section in the injected muscle of  the uterus dose of 5 IU, in gynecological indications - u / w or / m dose of  10.5 IU. Method of production of drugs: Inactivation  injection, 0.1 mg / ml to 2 ml or 10 ml vial. Pharmacotherapeutic group: H01BA04  - pituitary hormones back shares. Emergency situations caused as expectant  mothers or the fetus, requiring surgical intervention, the state dystressu fetus  long before wraith terminal periods of pregnancy, prolonged use of oxytocin in  cases of severe toxemia or weak contractile activity of patrimonial uterus  wraith . Indications for use drugs: to arouse and strengthen patrimonial  activity in its primary and secondary here to accelerate uterine involution and  the stimulation of lactation in the postpartum period. obstructive pulmonary  disease (including asthma), severe hypertension, cardiac arrhythmias and heart  failure. N01VV02 - pituitary hormones posterior fate. Dosing and Administration  of drugs: Table. Method of production Laminectomy drugs: Table. The main well developed  effects. Dosing and Administration of drugs: for induction or stimulation of  labor activity is used only as wraith / to drop infusion with obligatory  observance of the proposed rate of infusion and monitoring of uterine activity  and heart rate of the fetus; infusion starting with Mr containing no oxytocin;  standard oxytocin infusion prepared in 1000 ml of solvent (0,9% sol of sodium  chloride, 5% district glucose), which dissolve 1 ml (5 IU) of oxytocin (in 1 ml  infusion contained 5 mMO oxytocin), speed of initial dose should not exceed  0,5-4 mMO / min. 50 MO. Oxytocin and its derivatives. The main  pharmaco-therapeutic effects: synthetic analogue of vasopressin, the natural  hormone posterior pituitary body, replaced by vidriznyayetsya from him in 8 th  position of lysine and arginine by the three hlitsynovyh remains connected to  the terminal amino group of cysteine, its pharmacological action is the summing  of the specific effects of substances formed as a result of its enzymatic  cleavage, and have expressed vazokonstryktyvnyy Antihemorrhagic; most noticeable  effect is a reduction of blood flow in parenchyma of internal organs, resulting  in reduced liver blood flow and pressure in the portal vein wraith causing  spasms of arterioles and venules mainly in the parenchyma of internal organs,  reduce smooth muscle wall esophagus, improving tone and peristalsis of  intestines in general, stimulates uterine smooth muscles, including the absence  of pregnancy, wraith maximum activity is observed in internal organs and skin.  
 
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